Xander Cage is left for dead after an incident, though he secretly returns to action for a new, tough assignment with his handler Augustus Gibbons.
A brutal home-jacking goes hopelessly wrong. Dave, one of the two robbers, manages to run off, leaving his brother Kenneth behind. Four years later, Kenneth is released from prison and much has changed. Dave has his life back on track and is trying to help Kenneth however possible, but is witnessing how the highly strung Kenneth tries to win back his ex-girlfriend Sylvie.
After waking up in a hospital with amnesia, professor Robert Langdon and a doctor must race against time to foil a deadly global plot.